Recruitment

Protein mass spectrometry toolkit for monitoring autophagy

Reference: ESR15/QPS The goal of this project is to develop a mass spectrometry (MS)-based read-out to evaluate autophagy progression. A major current limitation in assessing autophagy in animal models and monitoring the efficacy of autophagy-modulating therapies in patients is the…

Recruitment

Atg 1 as the master regulator of autophagy

Reference: ESR1/UMCG The goal of this project is to understand how the central kinase regulating autophagy modulates the formation and termination of autophagosome biogenesis. Recent evidences point to a regulation through phosphorylation/dephosphorylation of components of the ATG machinery. Understanding which…