Reference: ESR6/UKLFR In this project we want to understand the molecular mechanism of autophagosome formation by study the function of Atg11 and Atg17, two key factors in the initiation of this process. Atg17 dimers form a crescent structure, which is…
Reference: ESR5/UiO The goal of this project is to unravel the molecular mechanisms underlying the regulation and execution of selective autophagy of aggregate-prone proteins (aggrephagy). Such knowledge might pave the way for development of targeted therapies for neurodegenerative disorders. We…
Reference: ESR4/WIS The long-term goal of the proposed study is to determine the precise role of TECPR2 in intracellular vesicular trafficking and autophagy, and characterize the link between these processes and hereditary spastic paraparesis (SPG49). Our working hypothesis is that…
Reference: ESR3/UH The goal in this project is to elucidate the physiological function of the small GTPase RAB24 in neuronal cells. We showed recently that RAB24 is required for the clearance of autolysosomes under nutrient-rich conditions (Ylä-Anttila et al. 2015,…
Reference: ESR2/INEM The goal of this project is to develop new therapeutic strategies to cure ciliopathies. The primary cilium can be described as a coordinator of different signaling pathways (such as the Hedgehog pathway) during development and tissue homeostasis. Cilia…
Reference: ESR1/UMCG The goal of this project is to understand how the central kinase regulating autophagy modulates the formation and termination of autophagosome biogenesis. Recent evidences point to a regulation through phosphorylation/dephosphorylation of components of the ATG machinery. Understanding which…
Therapeutic particles targeting to induce autophagy as a tumor and neurodegeneration suppressor
High-throughput screening for compounds that modify autophagy
