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Protein mass spectrometry toolkit for monitoring autophagy
Reference: ESR15/QPS The goal of this project is to develop a mass spectrometry (MS)-based read-out to evaluate autophagy progression. A major current limitation in assessing autophagy in animal models and monitoring the efficacy of autophagy-modulating therapies in patients is the…
Design and evaluation of therapeutic biodegradable particles targeting inducing...
Reference: ESR14/ADJ The goal of this project is to develop and characterize safe biodegradable particles, vectorising immune-modulators able to induce autophagy and targeting liver to act as tumour suppressor in the context of chronic liver diseases or other cancers. Indeed,…
Drug discovery for new mitophagy regulators
Reference: ESR13/CSIC The main objective of this project is to identify new Parkin-dependent and Parkin-independent modulators of mitophagy. Our approach will use reverse chemical genetics with a phenotypic screen for mitophagy index in collaboration with the group of Patricia Boya…
High-throughput screening for compounds that modify autophagy
Reference: ESR12/IME-SP The objective of this project is the identification and characterization of novel small molecule compounds that modulate the autophagic flux within cells. Autophagy effector proteins are functionally altered in several diseases such as cancer, cardiomyopathies or degenerative diseases…
Deep-learning approaches integrated into the paradigms of systems biology to...
Reference: ESR11/AX The goal of this project is to contribute to the contextual understanding of autophagy in different pathological backgrounds using systems biology based approaches. A system view of the relevant physiological function is essential to uncover the molecular mechanisms…
Characterization of the p.Gln336Arg mouse model of EPG5-related Vici syndrome
Reference: ESR10/KINGS The goal of this project is to investigate the role of autophagy in a mouse model of early-onset neurodevelopmental disorders due to mutations in the key autophagy regulator EPG5. We have recently identified recessive mutations in EPG5 as…
Studying the role of selective autophagy in cancer
Reference: ESR9/ICR The goal of this project is to characterize the protective role of selective autophagy in human cancers, with the potential to develop novel therapeutic strategies in oncology. Defects in selective autophagy have been linked to tumorigenesis. The underlying…
PROPPIN regulation in cancer and autophagy
Reference: ESR8/EKU Objectives: The goal of this project is to acquire new knowledge about the signaling networks regulating autophagy in health and cancer. Human PROPPINs, referred to as WIPI (WIPI1-4), are associated with age-related human diseases, such as cancer and…
The role of autophagy during retinal development
Reference: ESR7/CSIC The main objective of this project is to understand the role of autophagy for retinal ganglion cell survival during retinal development. Retinal ganglion cells are the only projecting neurons of the retina and their axons form the optic…
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