Reference: ESR15/QPS The goal of this project is to develop a mass spectrometry (MS)-based read-out to evaluate autophagy progression. A major current limitation in assessing autophagy in animal models and monitoring the efficacy of autophagy-modulating therapies in patients is the…
Reference: ESR14/ADJ The goal of this project is to develop and characterize safe biodegradable particles, vectorising immune-modulators able to induce autophagy and targeting liver to act as tumour suppressor in the context of chronic liver diseases or other cancers. Indeed,…
Reference: ESR13/CSIC The main objective of this project is to identify new Parkin-dependent and Parkin-independent modulators of mitophagy. Our approach will use reverse chemical genetics with a phenotypic screen for mitophagy index in collaboration with the group of Patricia Boya…
Reference: ESR12/IME-SP The objective of this project is the identification and characterization of novel small molecule compounds that modulate the autophagic flux within cells. Autophagy effector proteins are functionally altered in several diseases such as cancer, cardiomyopathies or degenerative diseases…
Reference: ESR11/AX The goal of this project is to contribute to the contextual understanding of autophagy in different pathological backgrounds using systems biology based approaches. A system view of the relevant physiological function is essential to uncover the molecular mechanisms…
Reference: ESR10/KINGS The goal of this project is to investigate the role of autophagy in a mouse model of early-onset neurodevelopmental disorders due to mutations in the key autophagy regulator EPG5. We have recently identified recessive mutations in EPG5 as…
Reference: ESR9/ICR The goal of this project is to characterize the protective role of selective autophagy in human cancers, with the potential to develop novel therapeutic strategies in oncology. Defects in selective autophagy have been linked to tumorigenesis. The underlying…
Reference: ESR8/EKU Objectives: The goal of this project is to acquire new knowledge about the signaling networks regulating autophagy in health and cancer. Human PROPPINs, referred to as WIPI (WIPI1-4), are associated with age-related human diseases, such as cancer and…
Reference: ESR7/CSIC The main objective of this project is to understand the role of autophagy for retinal ganglion cell survival during retinal development. Retinal ganglion cells are the only projecting neurons of the retina and their axons form the optic…
Reference: ESR6/UKLFR In this project we want to understand the molecular mechanism of autophagosome formation by study the function of Atg11 and Atg17, two key factors in the initiation of this process. Atg17 dimers form a crescent structure, which is…
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