Reference: ESR12/IME-SP The objective of this project is the identification and characterization of novel small molecule compounds that modulate the autophagic flux within cells. Autophagy effector proteins are functionally altered in several diseases such as cancer, cardiomyopathies or degenerative diseases…
Reference: ESR8/EKU Objectives: The goal of this project is to acquire new knowledge about the signaling networks regulating autophagy in health and cancer. Human PROPPINs, referred to as WIPI (WIPI1-4), are associated with age-related human diseases, such as cancer and…
Reference: ESR6/UKLFR In this project we want to understand the molecular mechanism of autophagosome formation by study the function of Atg11 and Atg17, two key factors in the initiation of this process. Atg17 dimers form a crescent structure, which is…
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